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上海中藥創新研究中心

上海中藥創新研究中心

      上海中藥創新研究中心(以下簡稱“中心”)是在中國科技部和上海市人民政府的支持下,于 2000 年 4 月由上海市科委、上海市浦東新區政府和上海市張江高科技園區開發公司共同投資組建的中藥現代化研究和開發機構,是國家中藥現代化(上海)創新中心的依托單位,是國家生物醫藥基地重點建設的國家級專業孵化器之一,也是國家國際科技合作基地和上海市研究生聯合培養基地。

      Shanghai Innovative Research Center of Traditional Chinese Medicine (SIRC/TCM), as a research and development (R&D) institution for TCM modernization, was co-founded by Science and Technology Committee of Shanghai, Pudong New Area Government of Shanghai and Shanghai Zhangjiang Hi-Tech Park Development Corporation in April 2000. With supports from Ministry of Science and Technology of China and Shanghai Municipal Government, SIRC/TCM is designated as a core Innovation Center of TCM Modernization in Shanghai, a national key incubator for biomedical research in China, an international science and technology cooperation base in China, and a post-graduation co-education base in Shanghai.

 

      作為國家級專業科研機構,中心以“市場為導向,創新為手段”,遵循“源于中藥、高于中藥”的研發理念,開創性地進行中藥新藥的探索研究,并獨立創建了中藥現代化的兩大創新研究體系:

1)世界一流的大型綜合性關聯型中藥數據庫;

2)吸收/代謝后單體組合藥物(PAMD)創新理念及其實驗方法。

      中藥數據庫囊括了三萬多個中草藥中天然含有的活性化合物及其他信息,涉及分子結構、生物活性、化合物來源(草藥)、毒性、中藥方劑以及臨床應用等。中藥數據庫已廣泛應用于篩選先導化合物、研究中藥作用機理、預見草藥方劑毒性以及開發全新中藥復方等。

      As a national R&D center, SIRC/TCM is innovation-oriented and market-guided with the mission of developing novel drugs that are “from TCM, better than TCM”. Our approach of TCM modernization is based on two innovations generated by SIRC scientists: 1) a world-class comprehensive and interactive TCM database; 2) a novel concept of Post-Absorption and Metabolism Drugs (PAMD). The TCM database contains information about more than 30,000 compounds that are active ingredients of TCM herbs. The interactive structure of this database provides information of these compounds in a range of molecular structure, biological activity, herbs containing those compounds, toxicity, as well as TCM formula and their clinical application. The database has been widely used in screening for lead compounds, studying mechanisms of TCM drugs, predicting toxicity of herbal combinations, as well as creating new TCM formulas.

 

      PAMD研究理念旨在從口服草藥后存留于體內的化合物中探尋新藥,而且這些草藥的臨床療效確切,安全性穩定、可靠。因為人體吸收的化合物數量不足中藥方劑所含化合物的1%,而且其中大量化合物是原有活性成分的代謝物,所以運用PAMD策略可以極大地提高從中藥中探索先導化合物的效率,以研發新的單體化合物藥物以及來自中藥復方的組合化合物藥物。中心已經成功研發了一系列擁有自主知識產權的新藥,其中多個新藥即將進入臨床研究甚至已經上市。

      The concept of PAMD is to seek drug candidates among compounds existing in our body after orally taking TCM herbs, of which are with proven clinical benefits and demonstrated safety profiles. Given the fact that compounds absorbed by our body is less than 1% of those contained in TCM formula and many of them are metabolites of original active ingredients, PAMD strategy drastically improved efficiency in finding lead compounds from TCM for development of new single compound drugs as well as compound-combinations derived from TCM formulas. With the PAMD strategy, a series of proprietary drug candidates and products have been developed and some of them are near clinical stage or already on the market.

      中心的研發技術平臺融合中藥數據庫、植物化學、分析技術、有機合成、分子藥理學、細胞生物學、毒理、中藥基因組、轉錄組學、代謝組學、藥效動力學、計算機輔助藥物設計、公斤級化學合成等多個學科。我們與國內外科學家和制藥廠商保持廣泛密切的聯系和合作。我們深信,中藥作為中國幾千年臨床應用實踐證明了的無價瑰寶,若能融合創新研發理念和先進實驗技術,那么古老而神秘的中藥必將引入現代醫學殿堂,為現代藥物研發帶來劃時代的變革。

      Research at SIRC/TCM employs a broad technological platform that integrates TCM informatics, phytochemistry, analytical technology, organic synthesis, molecular pharmacology, cell biology, toxicology, TCM genomics, transcriptomics, metabolomics, pharmacokinetics, computer-aid drug design and kilogram-scale chemical synthesis. We are well-connected with national and international scientists and pharmaceutical industries. People at SIRC/TCM believe that TCM is priceless treasure generated by Chinese people through clinical practice in past thousands of years and that innovative concepts with integrative technologies will eventually bring the ancient TCM to the modern medical sciences and revolutionize our approach in drug discovery as well as development of the modern pharmaceutical industry.


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